Kurisu Makise is the female protagonist of the anime series Steins;Gate and the love interest of Rintarou Okabe. Kurisu is a research member in Victor Qondria University's Brain Research Program. Her age group matches that of third-year high schoolers, but she skipped a grade through America's educational system. She is also famous in America for writing theses papers, part of which is covered in the news. Thanks to skipping a grade in America as a girl, she was envied by people around her, and ended up building a strong personality. She does not want to show weakness to others, so she always has a stern expression. However, she is very curious, and when she builds interest, she pokes into things. Occasionally, she has views that differ from regular opinions, such as, "The experiment data is more important than the subject's privacy."

Makise Kurisu first meets Rintarou Okabe at the Akihabara Radio Hall, claiming to have bumped into him 15 minutes earlier. She is later found by Rintarou lying in a pool of blood, and Rintarou texts Itaru about it.

After everyone's memories apparently disappear, Rintarou meets her, apparently in perfect health, at a lecture. He touches her hair in an attempt to verify that she is actually alive, and they argue until Kurisu has to begin the lecture. At the beginning of the seminar, she claims that time machines are impossible, resulting in Rintarou challenging her claim, and she turns the lecture into a discussion. She joins the Future Gadget Lab as Member 004 after a series of encounters with Rintarou Okabe. Rintarou has given her plenty of nicknames, in particular "Christina" and "Assistant".

Kurisu and her father are not on the best terms. When she was little, her father's lectures would fascinate her so much that she would read up on them herself. It was not long before she started getting into the science field. Because of her talent, she would always outsmart her own father, causing the two to come to bad terms.

At the end of the series, Okabe manages to save her without altering the past. She doesn't remember her time with him in other timelines, but she does have some subconscious memories and lingering feelings for him.

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